Please read this license agreement carefully before opening the software package. Analysis software module adds safety and toxicity analysis capability to flipr tetra high throughput cellular screening system. Parallel performance comparison of fluo3 and fluo4 on. May 24, 2012 molecular devices, llc, has introduced the screenworks peak pro analysis module for the flipr tetra system. For more information about flipr tetra, flipr reagent kits, and flipr accessories, contact your molecular devices representative or visit our web site at. Other highly important aspect for effective drug development is the assessment of cardiac safety and efficacy of drug candidates. Click here for more information on purchasing assay kits outside of the united states. Built as the most comprehensive calcium portfolio, the flipr calcium assay kits measure changes in intracellular calcium during drug discovery and research. Its throughput screening solutions helps in early identity for leads in the drug discovery process and community.
Molecular devices introduces flipr calcium 6 assay kits. Apr 23, 20 sunnyvale, california, april 23 20 molecular devices announced today the launch of flipr calcium 6 assay kits, the latest addition to their extensive range of calcium assay kits to address diversified gpcr and ion channel targets. Flipr calcium 5 assay kit molecular devices online store. Flipr membrane potential assay kit molecular devices. Flipr tetra highthroughput cellular screening molecular devices. Molecular devices acquired universal imaging corporation in 2002, axon instruments in 2004, and blueshift technologies in 2008, broadening its portfolio to include electrophysiology products, scanners and analysis software for microarrays, and workstations for cell. These cellbased, nowash kits were developed for molecular devices flipr and flexstation systems for gpcr screening and assay development. Molecular devices corporation developed the flipr membrane potential assay kit to provide a fast, simple and reliable fluorescence assay for detecting.
Our integrated solutions team, with extensive, multidisciplinary training and experience in mechanical, electrical and systems engineering, software development, and project management, has successfully integrated more than 300 thirdparty devices from over 60 manufacturers to meet our customers diverse automation needs. Eliminate 5060 hz linefrequency noise in less than one. Item vendor catalog number equipment flipr tetra high throughput cellular screening system flipr tetra system molecular devices consumables. Introduces screenworks peak pro software enabling high throughput cardiotoxicity screening published. Molecular devices is one of the worlds leading providers of highperformance bioanalytical measurement systems, software and consumables for life science research, pharmaceutical and. Development of a highthroughput bioassay to screen melatonin receptor agonists using human melatonin receptor expressing cho cells. R8190 flipr calcium 6 explorer kit flipr calcium 6 assay. With the flipr 384, you get the sensitivity, data fidelity, and realtime, kinetic information of the flipr i system in a 384well mode. Development of a highthroughput bioassay to screen. Flipr calcium 6 assay kit molecular devices online store. President of molecular devices provides an overview of our sophisticated portfolio and its impact on the development of novel therapeutics.
Flexible platform for cellbased hts the ability to configure instruments through varying stages of the drug discovery screening process is a challenge that requires instrument hardware flexibility and an easytouse software interface. Flipr penta system highspeed camera option and the new peak pro 2 software module allow realtime screening of ipscderived cardiomyocytes or. Molecular devices addresses these challenges with the fliprtetra system for kinetic cellbased screening. However the initial investment is a significant hurdle, especially for such a specialized instrument. Molecular devices flipr tetra highthroughput cellular. The software offers the ability to analyze multipeak calcium oscillation responses of cells, and in particular. Apr 28, 2017 she now works as a field applications scientist at molecular devices supporting reagents, flexstation3 reader, flipr tetra system, and automated electrophysiology platforms. Jan 16, 2020 the molecular devices flipr penta with the peak pro 2 software, tailored especially for kinetic screening for toxicology and lead compound identification, is a customizable, allinone highthroughput cellular screening system. Development of a robust gabab calcium signaling cell line. I agree to share the above information with molecular devices and researchgate so i may receive the requested material and communications from molecular devices about their products and special. Featuring a proprietary fluorophore, the dye offers the highest quantum yield of any calcium indicator on the market, delivering the greatest signal window available in a calcium assay kit. Molecular devices features cardiomyocyte screening with.
Flipr calcium 4 nowash dye molecular devices and bd calcium assay bd biosciences kits were diluted in physiological salt solution as per manufacturers instructions. Molecular devices corporation developed the flipr membrane potential assay kit to provide a fast, simple and reliable fluorescence assay for detecting changes in membrane potential. Molecular devices your scientific network labroots. Flipr membrane potential assay kits molecular devices. Molecular devicess competitors, revenue, number of employees. Introducing screenworks peak pro software for flipr tetra. Molecular devices is committed to the continual development of innovative. Molecular devices offers a full range of systems to suit a wide range of laboratory functions, which include.
Flipr analysis was performed on the flipr 384 system molecular device, sunnyvale, ca. The flipr is a high throughput imaging plate reader that has contributed substantially to drug. An industryrecognized software with over 100,000 users world wide is built on over 25 years of experience. Molecular devices is one of the leading provider of highperformance bioanalytical measurement solutions for life science research, pharmaceutical and biotherapeutic development. Our products enable scientists to improve productivity and efficiency in scientific discovery and research. This assay provides a level of information approaching that of patch clamping.
Superior signaltonoise ratio facilitates confirmation of endogenous or transiently transfected receptor activity during assay development. User friendly software for data acquisition and analysis. This application note describes a simple and effective elisa method used on an absorbance microplate reader to test for potential contaminants in cannabis. Unfortunately, poorly integrated tools and software analysis programs have created a significant barrier to developing assays and obtaining fast. Ebook eliminate 5060 hz linefrequency noise in less than one second. Molecular devices emax plus microplate reader for sale labx. R8190 flipr calcium 6 explorer kit flipr calcium 6 assay kits, molecular devices each. Flipr calcium assay kits provide the most comprehensive method for measuring changes of intracellular calcium for drug discovery and basic research and act as portfolio of calcium reagents. Molecular devices flipr tetra system for sale labx. The software offers the ability to analyze multipeak calcium oscillation responses of cells, and in particular beating cardiomyocytes, to characterize cardiotoxic and cardioactive compounds during a high throughput screen.
Experimental services science exchange lets you compare quotes. These products bolster the already substantial cell imaging product offerings of molecular devices, which include the fluorometric imaging plate reader flipr system, along with updated versions flipr 2, flipr 3 and the chemiluminescence imaging plate reader clipr highthroughput cellbased assay screening system. This instrument is designed to run both read and pipetting functions concurrently, making it the ideal system for rapid kinetic cellular assays, including those for. Configuration description part number explorer kit. In drug discovery and research environments, molecular devices calcium flux assay kits, introduced in 1999, have become the platform of choice for measuring gpcr calcium mobilization in cellbased assays. The molecular devices flipr tetra highthroughput cellular screening system features simultaneous pipette and read capability which helps in fast kinetic cellular assays, such as calcium flux. The molecular devices flipr tetra is a high throughput cellular screening platform offering superior performance and consistency in conducting real time kinetic cellular assays. Flipr calcium assay kits provide the most comprehensive method for measuring. Development of a robust gaba b calcium signaling cell line using lactamase technology and sorting. The flexstation 3 multimode microplate reader for absorbance, fluorescence intensity, fluorescence polarization, luminescence, and timeresolved fluorescence measurements. For the double addition protocols, compounds were added by the flipr, and readings were taken for 3 min, followed by the addition of the agonist. New and used molecular devices emax plus microplate readers for sale on labx. Parallel performance comparison of fluo3 and fluo4 on molecular devices flipr systemtable 19. Molecular devices, announced the launch of the next generation of its flipr penta.
Molecular devices announced today the launch of flipr calcium 6 assay kits, the latest addition to their extensive range of calcium assay kits to address diversified gpcr and ion channel targets. Introducing screenworks peak pro software for flipr. Development of a highthroughput fluorescent nowash sodium. Molecular devices launches highcontent imaging system with. Configuration description part number explorer kit 10 vials of component. Molecular devices introduces the flipr penta system. The right to use this molecular devices corporation mdc software is sold only on the condition that the user agrees to the terms of this license agreement. The flipr 384 system fluorometric imaging plate reader. This instrument is designed to run both read and pipetting functions concurrently, making it the ideal system for rapid kinetic cellular assays, including those for calcium flux, gpcr and ion channel read more.
Molecular devicess competitors, revenue, number of employees, funding and acquisitions molecular devicess website molecular devices is a provider of bioanalytical measurement systems, software and consumables for life science research. Weve found molecular devices to be one of the more responsive manufacturers of the many we deal with. Lwell fluo4am or commercial assay kits and cells were incubated in the dark at 37c for 30 min. Flipr tetra high throughput cellular screening system from. In combination with the flipr system, it provides a very good. Aug 02, 2019 find out more about the new flipr penta.
Molecular devices is one of the worlds leading providers of highperformance bioanalytical measurement systems, software and consumables for life science research, pharmaceutical and biotherapeutic development. Flipr has been recently developed to measure the cellular signal with fluorescent dyes. Flipr calcium 4 assay kit, bulk from molecular devices llc. Each kit uses a proprietary indicator dye, combined with different quencher to maximize cell linechannelcompound applicability while eliminating causes of variability in the data. Included within a broad product portfolio are platforms for highthroughput screening, genomic and cellular analysis, colony selection. Flipr tetra highthroughput cellular screening molecular. Molecular devices flipr tips molecular devices online store. About molecular devices, llc molecular devices is one of the worlds leading providers of highperformance bioanalytical measurement systems, software and consumables for life science research, pharmaceutical and biotherapeutic development. The measurement of the cellular calcium concentration is completed in about 2 min with a 96well format. Feb 14, 2012 sunnyvale, ca february 14, 2012 molecular devices, llc, introduces the screenworks peak pro analysis module for the flipr tetra system. Ensure your assay quality with quality tips certified rnasednasefree nonpyrogenic nonsterile.
Required equipment, consumables, and software the following equipment, consumables, and software are required in addition to the materials specified in the icell cardiomyocytes users guide. Cellular assays have always been a powerful tool in the research lab. Preoptimized and validated protocols for the flipr tetra and flexstation systems ensure you can navigate both routine and unconventional cell lines and targets available configurations. Flipr calcium assay kits from molecular devices employ sensitive calcium. The assay was successfully miniaturized to 1536well format using a molecular devices standard membrane potential dye. Molecular devices flipr tetra system the fliprtetra system steps forward to deliver an entirely new screening platform to address realtime kinetic cellbased assays. Pdf development and optimization of flipr high throughput.
The flipr calcium 5 assay kit utilizes a unique fluorophore that exhibits a large signal window, and is amenable to incubation at 37c or room temperature, facilitating fullyautomated screens that may run overnight. Broadest selection of calcium kits to address diversified gpcr and ion channel targets flipr calcium 6 assay kits boost calcium signals, allowing you to screen poor responders while tailoring conditions to your targets specific needs. Molecular devices introduces screenworks peak pro software. With the rapid development of nanotechnology and indepth research, researchers have made progress in the theory and practice of molecular electronic devices in recent years.
Molecular devices introduces the flipr penta system molecular. The molecular devices online store is currently available to shipping addresses within the united states only. They are incredibly versatile, and can be designed to measure virtually any cellular or biochemical function. Flipr penta highthroughput cellular screening system. Slas 2016 accelerate your discoveries with molecular devices.
The trademarks used herein are the property of molecular devices, llc. Innovative solutions for drug discovery and life sciences. The humsilencer feature of the axon digidata system learns, adapts, and eliminates local 5060 hz linefrequency noise patterns and associated highfrequency harmonics from incoming signals on up to four channels in parallel. Purchase and get quotes on the products you need for your lab. Softmax pro users manual iii softmax pro license agreement and warranty important. Molecular devices is a leading provider of highperformance bioanalytical measurement solutions for life science research, pharmaceutical development, and biotherapeutic discovery with over,000 instrument placements in laboratories around the world that. Molecular devices features cardiomyocyte screening with the. Membrane potential assay kit to provide a fast, simple and reliable. The flipr fluorometric imaging plate reader system addresses the industrys requirements for higher throughput, minimized sample volume, and cost reduction. The analyst, flexstation and spectramax m5m5 e from molecular devices have received the lanthascreen certified designation from life technologies which ensures that these readers are validated to strict standards in instrument setup and assay performance. You need to conduct assay development or drug screening for cancer research using biologically relevant cell models. Measuring membrane potential using the flipr membrane.
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